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Transient Lesion in the Splenium of the corpus callosum: Three Further Cases in Epileptic Patients and a Pathophysiological Hypothesis JNNP 70:459-463, Polster,T.,et al, 2001 See this aricle in Pubmed Article Abstract A transient lesion in the SCC has so far only been described in 13 patients with epilepsy and has been interpreted either as reversible demyelination due to AED toxicity or transient oedema after secondary generalized seizures. The data con firm neither of these hypotheses. A transient lesion in the SCC seems to be a non-specific end point of different disease processes leading to a vasogenic oedema. This suggests, in these patients, a multifactorial pathology triggered by transient effect s of AEDs on arginine vasopressine and its function in fluid balance systems in a condition of vitamin deficiency. The complete and rapid reversibility in all cases without specific intervention is emphasized and any invasive diagnostic of therapeutic ap proach is discouraged.

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(click to filter results - removes previous filter) corpus callosum corpus callosum,lesion of MRI MRI,abnormal MRI,disappearing lesion on seizure splenium of corpus callosum

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